منابع مشابه
Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER.
Sterols inhibit their own synthesis in mammalian cells by blocking the vesicular endoplasmic reticulum-to-Golgi transport of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), a sterol-sensing protein that escorts SREBPs. Unable to reach the Golgi, SREBPs are not processed by Golgi-resident proteases, and they fail to activate genes required for cholesterol sy...
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Separation logic supports state-modular program verification in two aspects: local reasoning by means of the ordinary (first-order) frame rule and information hiding by the hypothetical frame rule (a second-order frame rule). In this paper, we show the support of local reasoning and information hiding in SCAP, a program logic for low-level programs with stack-based control abstractions. We show...
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Context. Photometric surveys of transNeptunian objects (TNOs) and Centaurs have suggested possible correlations between some orbital parameters and surface colors of classical objects, scattered disk objects (SDOs), and Centaurs. However, larger sample sizes are needed in order to corroborate or rule out the possible correlations and find some possible new ones. The implications from these corr...
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Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple accumulation of triglycerides in the hepatocytes to serious states accompanied by inflammation and fibrosis in the liver. De novo lipogenesis has been shown to be a significant factor in the development of hepatic steatosis ...
متن کاملCholesterol Contributes to Diabetic Nephropathy through SCAP-SREBP-2 Pathway
Diabetic nephropathy (DN) has been associated with the presence of lipid deposition. We hypothesized that the disruption of intracellular cholesterol feedback may contribute to DN. Diabetes was induced by high fat/sucrose diet and low-dose intraperitoneal injection of streptozocin (STZ) in male Sprague-Dawley rats. Then diabetic rats were randomly divided into two groups: untreated diabetic gro...
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ژورنال
عنوان ژورنال: Astronomy & Geophysics
سال: 2000
ISSN: 1366-8781
DOI: 10.1046/j.1468-4004.2000.00414-2.x